Until now, gene editing has relied on cell division to propagate modifications made with techniques like CRISPR Cas9. Researchers at the Salk Institute have devised a new method that can modify the genes of non-dividing cells (the majority of adult cells). They demonstrated the method’s potential by inserting missing genes into the brains of young mice that were blind due to retinitis pigmentosa. After the team inserted fully functional copies of the damaged gene responsible for the condition into the relevant visual neurons, the mice experience rudimentary vision.
Team leader Izpisua Belmonte says of the new method, homology-independent targeted integration (HITI), “We now have a technology that allows us to modify the DNA of non-dividing cells, to fix broken genes in the brain, heart and liver. It allows us for the first time to be able to dream of curing diseases that we couldn’t before, which is exciting.”
While the team, naturally and appropriately, envisions therapeutic uses, could this method be used to modify brain function non-therapeutically, to improve normal functioning, for example?
Good discussion that covered a lot of ground. I took away that none of us have signed on to be early adopters of brain augmentations, but some expect development of body and brain augmentations to continue and accelerate. We also considered the idea of bio-engineered and medical paths to significant life-span, health, and cognitive capacity improvements. I appreciated the ethical and value questions (Why pursue any of this? What would/must one give up to become transhuman? Will the health and lifespan enhancements be equally available to all? What could be the downsides of extremely extended lives?) Also, isn’t there considerable opportunity for smarter transhumans, along with AI tools, to vastly improve the lives of many people by finding ways to mitigate problems we’ve inherited (disease, etc.) and created (pollution, conflict, etc.)?
TED talk of possible interest:
Comment I posted there:
Here is an interdisciplinary “moon-shot” suggestion that we should at least start talking about, now, before it is too late. Let’s massively collaborate to develop a very mission-specific AI system to help us figure out, using emerging genetic editing technologies (e.g., CRISPR, etc.), ideally how to tweak (most likely) species-typical genes currently constraining our capacities for prosociality, biophilia, and compassion, so that we can intentionally evolve into a sustainable species. This is something that natural selection, our past and current psycho-eugenicist, will never do (it cannot), and something that our current genetic endowment will never allow cultural processes / social engineering approaches to adequately transform us. Purposed-designed AI systems feeding off of growing databases of intra-genomic dynamics and gene-environment interactions could greatly speed our understanding of how to make these genetic adjustments to ourselves, the only hope for our survival, in a morally optimal (i.e., fewest mistakes due to unexpected gene-gene and gene-regulatory (exome) and epigenetic interactions; fewest onerous side-effects) as well as in a maximally effective and efficient way. Come together, teams of AI scientists and geneticists! We need to grab our collective pan-cultural intrapsychic fate away from the dark hands of natural selection, and AI can probably help. END