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Tag: synapses

Fast mapping technique will revolutionize brain research

Fast mapping technique will revolutionize brain research

Tony Zador of Cold Spring Harbor Laboratory devised a new technique for mapping connections among neurons. It is much faster than other methods and at least as accurate as the most accurate competing methods, including fluorescence techniques. The technique, MAPseq, uses genetically modified viruses to insert unique RNA sequences (“bar codes”) into each neuron. Post-mortem DNA sequencing identifies connections among all neurons in the sample. The resulting model is structural, not functional. Derived models are not spatially accurate (i.e., not…

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70-year-old Hebbs synaptic learning theory wrong

70-year-old Hebbs synaptic learning theory wrong

Neural learning occurs at dendrite roots, not in synapses. The newly suggested learning scenario indicates that learning occurs in a few dendrites that are in much closer proximity to the neuron, as opposed to the previous notion. … The new learning scenario occurs in different sites of the brain and therefore calls for a reevaluation of current treatments for disordered brain functionality. … In addition, the learning mechanism is at the basis of recent advanced machine learning and deep learning…

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Neuroplasticity at the neuron and synapse level – Neurons sort into functional networks

Neuroplasticity at the neuron and synapse level – Neurons sort into functional networks

“Individual neurons whose synapses are most likely to strengthen in response to a certain experience are more likely to connect to certain partner neurons, while those whose synapses weaken in response to a similar experience are more likely to connect to other partner neurons,” Friedlander said. “The neurons whose synapses do not change at all in response to that same experience are more likely to connect to yet other partner neurons, forming a more stable but non-plastic network.”